Research

NASOIE is committed to supporting dissemination of knowledge regarding interventional endocrinology techniques, and furthering research in this area. NASOIE members’ research activities and publications are available through our website. If not already listed, members may have their publications/clinical trials added by contacting [email protected].

Publications by NASOIE members

Original Research

September

2023

Effect of Ultrasound Guided Laser Ablation Therapy on Symptomatic Benign Thyroid Nodules, using EchoLaser, results of a pilot study in the US

The pilot study evaluates the efficacy of a single ultrasound-guided laser ablation treatment in an outpatient setting for symptomatic benign thyroid nodules, offering an alternative to traditional surgical methods.

Johnson Thomas MD, Gregory A. Ledger, Tracy Haertling

July

2023

Radiofrequency Ablation of Cervical Thyroid Cancer Metastases—Experience of Endocrinology Practices in the United States

To evaluate the efficacy RFA for the treatment of cervical recurrence/persistence of PTC in the United States.

Shahzad Ahmad, Jules Aljammal, Ian Orozco, Sheharyar Raashid, Fizza Zulfiqar, Sean P Nikravan, Iram Hussain

November

2022

Radiofrequency Ablation Performed By Endocrinologists Is A Viable Treatment Option For Recurrent Thyroid Cancer In The Outpatient Community Setting In The United States

To determine if radiofrequency ablation (RFA) performed by endocrinologists for recurrent thyroid cancer in the neck is a treatment option in the outpatient community setting in the USA.

Shahzad Ahmad, Jules Aljammal, Ian James Orozco, Sean P Nikravan, Fizza Zulfiqar, Sheharyar Raashid, Iram Hussain

August

2021

Safety and Efficacy of Radiofrequency Ablation of Thyroid Nodules—Expanding Treatment Options in the United States

Radiofrequency ablation (RFA) has only recently gained popularity in the United States for treatment of thyroid nodules (TNs), with a limited number of patients having undergone the procedure in this country.
Iram Hussain, Fizza Zulfiqar, Xilong Li, Shahzad Ahmad, Jules Aljammal

August

2015

Health-Related Quality of Life After Percutaneous Radiofrequency Ablation of Cold, Solid, Benign Thyroid Nodules: A 2-Year Follow-Up Study in 40 Patients

We studied the impact of radiofrequency ablation (RFA) on health-related quality of life (HRQL) in patients with benign thyroid nodules (TN) in a 2-year follow-up.

RobertoValcavi MD, Petros Tsamatropoulos MD

November

2012

Long-Term Effectiveness of Ultrasound-Guided Laser Ablation of Hyperfunctioning Parathyroid Adenomas: Present and Future Perspectives

Although surgery is the first-choice treatment of primary hyperparathyroidism (pHPT), some patients present with contraindications or refuse surgery. Data from alternative nonsurgical therapies are inconclusive. To study the long-term efficacy of laser ablation in the treatment of pHPT, we retrospectively reviewed six cases of laser-treated patients.

Massimiliano Andrioli, Fabrizio Riganti, Claudio Maurizio Pacella1 and Roberto Valcavi

January

2012

Pathological Findings of Thyroid Nodules After Percutaneous Laser Ablation

Ultrasound (US)-guided percutaneous laser ablation (LA) of benign thyroid nodules may be a potential alternative to surgery in patients with compressive symptoms, at high surgical risk, or in patients who refuse to undergo surgery.

Simonetta Piana, Fabrizio Riganti, Elisabetta Froio, Massimiliano Andrioli, Claudio M. Pacella & Roberto Valcavi

November

2010

Percutaneous Laser Ablation of Cold Benign Thyroid Nodules: A 3-Year Follow-Up Study in 122 Patients

Percutaneous laser ablation (PLA) is a proposed therapeutic procedure for the management of benign thyroid nodules. However, long-term results are unknown. The aim of this study was to evaluate retrospectively the safety and effects of PLA treatment in patients with benign nonfunctioning thyroid nodules in a 3-year follow-up.

Roberto Valcavi, Fabrizio Riganti, Angelo Bertani, Debora Formisano, and Claudio M. Pacella

May

2004

Ultrasound-Guided Percutaneous Ethanol Injection Therapy in Thyroid Cystic Nodules

To provide an overview of ultrasound (US)-guided percutaneous ethanol injection (PEI) therapy for thyroid cystic nodules and discuss the practical and technical details.

Roberto Valcavi MD & Andrea Frasoldati MD, PhD

Case Reports

June

2023

Hyperthyroidism Due to Graves Disease After Radiofrequency Ablation

Management options for benign, autonomously functioning, and malignant thyroid nodules were limited to surgery or targeting by radioactive iodine before the availability of radiofrequency ablation (RFA). Despite being a relatively new technique, RFA may be favored for patients of high surgical risk, and for those who wish to avoid hypothyroidism. Although insurance coverage for the procedure can be a significant barrier, several groups of investigators have shown improved quality of life for RFA compared to surgery, due to the less invasive nature and favorable risk profile

Elizabeth A McAninch, Kaniksha Desai, Karen C McCowen, Lisa A Orloff

December

2022

Radiofrequency Ablation Is a Thyroid Sparing Treatment Option for Primary Hyperparathyroidism Caused by an Intrathyroidal Parathyroid Adenoma

Recent studies report the incidence of intrathyroidal parathyroid adenomas to be between 1.3% and 2.4% in patients with primary hyperparathyroidism.1,2 The standard treatment for hyperparathyroidism caused by an intrathyroidal parathyroid adenoma has been surgery that often requires a lobectomy.

1 Treating primary hyperparathyroidism with radiofrequency ablation (RFA) has increasingly become an option as it has shown to be both safe and effective.3–7 We present a patient with primary hyperparathyroidism caused by a right-sided intrathyroidal parathyroid adenoma localized with fine needle aspiration (FNA) biopsy and parathyroid hormone (PTH) washout who is treated with RFA.

Jules Aljammal, Ian Orozco, Sheharyar Raashid and Shahzad Ahmad

November

2022

Radiofrequency Ablation of Recurrent Metastatic Papillary Thyroid Cancer to a Lymph Node

Although patients with papillary thyroid carcinoma have very favorable courses of treatment, locoregional recurrence to the neck based on risk factors can range from 20-60%.1

In the cases where surgery is contraindicated or refused by the patient for recurrent thyroid malignancy, ATA guidelines propose radiofrequency ablation (RFA) as a possible treatment option. RFA has emerged as an effective treatment option for various solid types of cancer

Shahzad Ahmad MD, FACE, ECNU, Ian James Orozco MD, ECNU, Sheheryar Raashid MD, Zainab Hamid MBBS, Jules Aljammal MD, ECNU

February

2022

Management of Recurrent Laryngeal Nerve Injury During Radiofrequency Ablation of Thyroid Nodules

Although radiofrequency ablation (RFA) is a safe and effective treatment for benign thyroid nodules,1,2 the proximity of the recurrent laryngeal nerve (RLN) to the posterior part of the thyroid gland in the tracheoesophageal groove3 puts it at risk of thermal injury during the procedure. Most RLN injuries result in immediate voice change. No standardized protocol has been described to treat this; however, the injection of cold dextrose 5% in water (D5W) around the RLN has been shown to improve symptoms of nerve damage during RFA in recent retrospective studies.4,5 In this video, we present this technique.
Jules Aljammal, MD, Iram Hussain, MD, Shahzad Ahmad MD

May

2021

Radiofrequency Ablation of Parathyroid Adenoma: A Novel Treatment Option for Primary Hyperparathyroidism

To present radiofrequency ablation (RFA) of parathyroid adenomas as a safe and effective management strategy for primary hyperparathyroidism in patients who are not eligible for surgery or those who do not want surgery.
Iram Hussain, MD, Shahzad Ahmad, MD, Jules Aljammal, MD

Reviews

December

2022

Beyond the AJR: The Emerging Role of Radiofrequency Ablation in the Treatment of Low-Risk Papillary Microcarcinoma of the Thyroid

Michael L. Douek and David S. K. Lu

April

2022

American Association of Clinical Endocrinology Disease State Clinical Review: The Clinical Utility of Minimally Invasive Interventional Procedures in the Management of Benign and Malignant Thyroid Lesions

The objective of this disease state clinical review is to provide clinicians with a summary of the nonsurgical, minimally invasive approaches to managing thyroid nodules/malignancy, including their indications, efficacy, side effects, and outcomes.

Sina Jasim, Kepal N. Patel, Gregory Randolph, Stephanie Adams, Roberto Cesareo, Edward Condon, Tara Henrichsen, Malak Itani, Maria Papaleontiou, Leonardo Rangel, John Schmit & Marius N.Stan

December

2015

Radiofrequency ablation for thyroid nodules: which indications? The first Italian opinion statement

Nodular thyroid disease is a very common finding in clinical practice, discovered by ultrasound (US) in about 50 % of the general population, with higher prevalence in women and in the elderly

Roberto Garberoglio, Camillo Aliberti, Marialuisa Appetecchia, Marco Attard, Giuseppe Boccuzzi, Flavio Boraso, Giorgio Borretta, ... more

June

2014

Ultrasound B-flow imaging in the evaluation of thermal ablation of thyroid nodules

The aim of percutaneous thermal ablation is to reduce the volume of benign thyroid nodules. B-flow imaging, a non-Doppler technology for blood flow imaging, provides a real-time visualization of vascularity, and gives accurate information on the vessel lumen in high spatial and temporal resolution. Little is known about the possible application of this new technique on thyroid nodules after thermal treatments.

Massimiliano Andrioli & Roberto Valcavi

March

2014

The peculiar ultrasonographic and elastographic features of thyroid nodules after treatment with laser or radiofrequency: similarities and differences

The aim of percutaneous thermal ablation with laser (LA) or radiofrequency (RFA) is to reduce the volume of benign thyroid nodules. Little is known about ultrasonographic and elastographic appearances of thyroid lesions after treatment.

Massimiliano Andrioli & Roberto Valcavi

September

2011

Thermal Ablation for Benign Thyroid Nodules: Radiofrequency and Laser

Although ethanol ablation has been successfully used to treat cystic thyroid nodules, this procedure is less effective when the thyroid nodules are solid. Radiofrequency (RF) ablation, a newer procedure used to treat malignant liver tumors, has been valuable in the treatment of benign thyroid nodules regardless of the extent of the solid component.

Jung Hwan Baek, Jeong Hyun Lee, Roberto Valcavi, Claudio M. Pacella, Hyunchul Rhim & Dong Gyu Na